7alpha, 25-dihydroxycholesterol (7alpha,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7alpha, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM, Kd=450 pM). 7alpha, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].
Molecular Weight:
418.65
Purity:
99.88
CAS Number:
[64907-22-8]
Formula:
C27H46O3
Target:
EBI2/GPR183,Endogenous Metabolite
Application Notes:
MCE Product type: Natural Products
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