PF-04859989 is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 µM, respectively)[1].
Molecular Weight:
178.19
CAS Number:
[34783-48-7]
Formula:
C9H10N2O2
Target:
Aminotransferases (Transaminases)
Application Notes:
MCE Product type: Reference compound
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