PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM, Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm[1][2].
Molecular Weight:
395.41
Purity:
99.95
CAS Number:
[1303420-67-8]
Formula:
C21H19F2N5O
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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