CDK8-IN-2 is an orally active CDK8 inhibitor of an IC50 values of 0.010 µM. CDK8-IN-2 shows a CDK19 IC50 value of 0.026 µM. CDK8-IN-2 inhibits phospho-STAT1, a pharmacodynamic biomarker of CDK8. CDK8-IN-2 inhibits WNT pathway activity. CDK8-IN-2 can be used for the research of colorectal carcinoma[1].
Molecular Weight:
319.37
CAS Number:
[1879980-97-8]
Formula:
C18H17N5O
Target:
5-HT Receptor,CDK,PASK/STK37,STAT,Wnt
Application Notes:
MCE Product type: Reference compound
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