RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 µM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutieres syndrome (AGS)[1].
Molecular Weight:
415.23
Purity:
99.95
CAS Number:
[2262452-06-0]
Formula:
C19H12Cl2N4O3
Target:
Cyclic GMP-AMP Synthase
Application Notes:
MCE Product type: Reference compound
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