MRK-740, a chemical probe, is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80?nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50?=?0.8?µM)[1].
Molecular Weight:
464.56
Purity:
99.84
CAS Number:
[2387510-80-5]
Formula:
C25H32N6O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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