Org 48762-0 (UR13870) is a potent, orally active and selective p38 inhibitor with an EC50 of 0.1 µM for p38alpha kinase. Org 48762-0 shows a high degree of kinase selectivity for p38alpha and p38beta over other kinases. Org 48762-0 reduces Lipopolysaccharides (HY-D1056) (LPS)-induced TNFalpha release. Org 48762-0 can be used for the study of rheumatoid arthritis (RA) and Werner syndrome[1][2].
Molecular Weight:
398.41
Purity:
99.99
CAS Number:
[755753-89-0]
Formula:
C24H16F2N4
Target:
p38 MAPK
Application Notes:
MCE Product type: Reference compound
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