Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC)[1][2][3][4][5][6].
Molecular Weight:
560.59
Purity:
99.90
CAS Number:
[2296729-00-3]
Formula:
C30H30F2N6O3
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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