RO5461111 a highly specific and orally active antagonist of Cathepsin S with IC50s of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. RO5461111 can effectively inhibit the activation of antigen-specific T cells and B cells. RO5461111 can improve pulmonary inflammation and lupus nephritis[1][2].
Molecular Weight:
614.56
Purity:
98.01
CAS Number:
[1252637-46-9]
Formula:
C27H24F6N4O4S
Target:
Cathepsin
Application Notes:
MCE Product type: Reference compound
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