Dihydrochalcone (3-Phenylpropiophenone) is a BBB-penatrable Abeta aggregation inhibitor. Dihydrochalcone destabilizes Abeta17-42 protofibrils by disrupting the beta-sheet of beta1 region. Dihydrochalcone destabilizes both U-shaped Abeta40/Abeta42 protofibrils and S-shaped Abeta42 protofibrils by binding to the protofibril cavity. Dihydrochalcone is the main component of daemonorops draco tree[1].
Molecular Weight:
210.27
Purity:
99.87
CAS Number:
[1083-30-3]
Formula:
C15H14O
Target:
Amyloid-beta
Application Notes:
MCE Product type: Reference compound
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