Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer[1][2][3][4].
Molecular Weight:
260.27
Purity:
99.84
CAS Number:
[60084-10-8]
Formula:
C9H12N2O5S
Target:
Nucleoside Antimetabolite/Analog,Orthopoxvirus
Application Notes:
MCE Product type: Reference compound
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