AMG-8562 is a TRPV1 modulator. AMG-8562 blocks Capsaicin (HY-10448) activation of TRPV1 without affecting heat activation of TRPV1. AMG-8562 potentiates pH 5 activation of TRPV1. AMG-8562 blocks capsaicin-induced flinching behavior in pain models. AMG-8562 produces significant efficacy in CFA- and skin incision-induced thermal hyperalgesia, and in the Acetic acid (HY-Y0319)-induced writhing models[1].
Molecular Weight:
430.47
CAS Number:
[1041478-78-7]
Formula:
C24H25F3N2O2
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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