AR-C117977 is a potent monocarboxylate transporter (MCT1) inhibitor. AR-C117977 prolongs the survival of skin and heart sllograft. AR-C117977 inhibits the development of transplant arteriosclerosis in aortic allografts partially, but was unable to inhibit alloantibody production after transplantation. AR-C117977 shows potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse[1].
Molecular Weight:
468.63
CAS Number:
[216685-07-3]
Formula:
C25H28N2O3S2
Target:
Monocarboxylate Transporter
Application Notes:
MCE Product type: Reference compound
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