D-Trp-Aib is a dipeptide and amyloid-beta inhibitor with a Kd of 29.6 nM. D-Trp-Aib triggers formation of non-toxic, non-beta-sheet, amorphous amyloid beta clusters from misfolded amyloid beta monomers and toxic amyloid beta oligomers, and reduces toxic amyloid beta1-42 deposits. D-Trp-Aib inhibits amyloid fibril formation of alpha-synuclein, IAPP and calcitonin. D-Trp-Aib can be used for the research of Alzheimers disease[1][2].
