BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 µM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC)[1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 µM[2].
Molecular Weight:
247.10
Purity:
99.85
CAS Number:
[34576-94-8]
Formula:
C9H4Cl2O2S
Target:
Bcl-2 Family
Application Notes:
MCE Product type: Reference compound
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