DPQ is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-kappaB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-alpha, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].
Molecular Weight:
302.41
Purity:
99.68
CAS Number:
[129075-73-6]
Formula:
C18H26N2O2
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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