ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 µM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke[1].
Molecular Weight:
328.75
CAS Number:
[1826026-00-9]
Formula:
C17H13ClN2O3
Target:
Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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