Feprazone (DA2370, Prenazone), an analogue of Phenylbutazone (HY-B0230), is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX)-2. Feprazone ameliorates free fatty acid (FFA)-induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity[1][2][3].
Molecular Weight:
320.39
Purity:
99.88
CAS Number:
[30748-29-9]
Formula:
C20H20N2O2
Target:
COX,MMP,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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