TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting beta-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer[1].
Molecular Weight:
278.36
CAS Number:
[59455-93-5]
Formula:
C18H18N2O
Target:
PARP,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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