EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 µM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease[1].
Molecular Weight:
362.38
CAS Number:
[220725-87-1]
Formula:
C20H18N4O3
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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