VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons[1][2].
Molecular Weight:
326.36
Purity:
99.84
CAS Number:
[1428630-85-6]
Formula:
C19H19FN2O2
Target:
mGluR,PERK
Application Notes:
MCE Product type: Reference compound
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