G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study[1].
Molecular Weight:
383.39
Purity:
99.55
CAS Number:
[939681-36-4]
Formula:
C22H19F2NO3
Target:
Apoptosis,JAK
Application Notes:
MCE Product type: Reference compound
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