NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity[1].
Molecular Weight:
369.41
CAS Number:
[150661-91-9]
Formula:
C18H38Cl2N2O
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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