GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 µM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 µM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 µM[1][2].
Molecular Weight:
429.58
CAS Number:
[171744-11-9]
Formula:
C23H31N3O3S
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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