ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from beta-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimers disease research[1].
Molecular Weight:
424.54
Purity:
99.08
CAS Number:
[1037837-27-6]
Formula:
C24H32N4O3
Target:
Apoptosis,COX,Interleukin Related,NO Synthase
Application Notes:
MCE Product type: Reference compound
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