(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 µM for disrupting the binding of 14-3-3zeta or 14-3-3gamma to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research[1].
Molecular Weight:
461.21
Purity:
95.63
CAS Number:
[1370281-06-3]
Formula:
C15H11N3Na3O8P
Target:
Ser/Thr Protease
Application Notes:
MCE Product type: Reference compound
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