UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM, Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].
Molecular Weight:
313.23
Purity:
98.84
CAS Number:
[1648707-58-7]
Formula:
C14H21BrN2O
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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