P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].
Molecular Weight:
392.15
Purity:
99.54
CAS Number:
[1809031-84-2]
Formula:
C14H9IN4O2
Target:
Autophagy,Mitophagy,Mitosis,p62
Application Notes:
MCE Product type: Reference compound
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