cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models[1].
Molecular Weight:
446.90
Purity:
99.82
CAS Number:
[2361988-77-2]
Formula:
C26H20ClFN2O2
Target:
Apoptosis,Caspase,RIP kinase
Application Notes:
MCE Product type: Reference compound1
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