GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2].
Molecular Weight:
575.72
Purity:
99.30
CAS Number:
[866924-39-2]
Formula:
C28H41N5O6S
Target:
MMP
Application Notes:
MCE Product type: Reference compound1
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