KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 µM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity[1][2].
Molecular Weight:
420.30
Purity:
99.46
CAS Number:
[1033781-20-2]
Formula:
C20H22BrNO4
Target:
Cryptochrome
Application Notes:
MCE Product type: Reference compound1
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