LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC50 = 0.28 mM). LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-kappaB. LQFM030 is commonly used in research on cancers such as leukemia[1].
Molecular Weight:
318.80
CAS Number:
[2180931-49-9]
Formula:
C16H19ClN4O
Target:
Apoptosis,Caspase,c-Myc,MDM-2/p53,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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