JNJ-7925476, CAS [[129540-12-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-116062A
Supplier Catalog Number:
HY-116062A
Alternative Catalog Number:
MCE-HY-116062A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression[1].
Molecular Weight:
273.37
CAS Number:
[129540-12-1]
Formula:
C20H19N
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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