A-424274 is a positive allosteric modulator of the alpha4beta2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the alpha4beta2 receptor and, in preclinical models, co-administration with an alpha4beta2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.
Molecular Weight:
225.29
CAS Number:
[1335145-56-6]
Formula:
C14H15N3
Target:
nAChR
Application Notes:
MCE Product type: Reference compound1
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