HUHS2002 is a free fatty acid derivative with the ability to enhance alpha7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of alpha7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay[1].
Molecular Weight:
276.37
CAS Number:
[1393102-59-4]
Formula:
C17H24O3
Target:
Cholinesterase (ChE)
Application Notes:
MCE Product type: Reference compound1
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