15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester (15(R)-17-phenyl trinor PGF2alpha isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (beta) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2alpha isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2alpha and 15(R)-17-phenyl trinor PGF2alpha were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 µg dose of 15(R)-17-phenyl trinor PGF2alpha caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
Molecular Weight:
430.58
CAS Number:
[130273-87-9]
Formula:
C26H38O5
Target:
Drug Intermediate
Application Notes:
MCE Product type: Reference compound1
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