SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression[1].
Molecular Weight:
344.24
Purity:
99.02
CAS Number:
[1548116-54-6]
Formula:
C15H19Cl2N3O2
Target:
Aldose Reductase
Application Notes:
MCE Product type: Reference compound1
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