PACA is an enhancer of nerve growth factor-induced neurite outgrowth, enhancing nerve growth factor (NGF)-induced neurite outgrowth and attenuating 6-hydroxydopamine (6-OHDA)-induced toxicity by activating the Nrf2/HO-1 pathway. PACA has neuroprotective and neurogenic activities. PACA can be used to improve dopaminergic neuron loss and motor dysfunction in MPTP mouse models of Parkinsons disease and MPP+-induced neurons[1][2].
Molecular Weight:
217.22
CAS Number:
[1431724-30-9]
Formula:
C12H11NO3
Target:
Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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