MS453 is a potent and highly selective SETD8 inhibitor with an IC50 value of 804 nM. MS453 specifically modifies a cysteine residue close to the inhibitor binding site. MS453 is selective for 28 other methyltransferases. The crystal structure of MS453 reveals its binding mode to SETD8, providing an atomic-level view for the development of high-quality chemical probes for SETD8[1].
Molecular Weight:
385.46
CAS Number:
[2059892-29-2]
Formula:
C20H27N5O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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