SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 µM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension[1].
Molecular Weight:
389.37
CAS Number:
[167298-74-0]
Formula:
C19H18F3N5O
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound1
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