Mps1/TTK-IN-1, CAS [[1202055-39-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-116470
Supplier Catalog Number:
HY-116470
Alternative Catalog Number:
MCE-HY-116470-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Mps1/TTK-IN-1 (Compound cpd-5), a derivative of NMS-P715 (HY-12382), is a Mps1 kinase inhibitor with an IC50 of 9.2 nM and a Kd of 1.6 nM. Mps1/TTK-IN-1 specifically targets the ATP-binding pocket of the Mps1 kinase. Mps1/TTK-IN-1 maintains inhibitory activity against Mps1 drug-resistant mutants (C604Y, C604W) with IC50 values of 170 and 19 nM and Kd values of 471 and 349 nM. Mps1/TTK-IN-1 can block the phosphorylation of kinetochore protein KNL1 mediated by Mps1, interfere with the spindle assembly checkpoint function, prevent the correct separation of chromosomes, and thereby inhibit the mitosis and proliferation of tumor cells[1].
Molecular Weight:
580.72
CAS Number:
[1202055-39-7]
Formula:
C33H40N8O2
Target:
Mps1
Application Notes:
MCE Product type: Reference compound
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