AF710B is an orally effective allosteric agonist for the M1 muscarinic receptor and sigma1 receptor. AF710B activates the downstream phosphorylated ERK1/2 and phosphorylated CREB signaling pathways. AF710B simultaneously improves cognitive function and alleviates the core pathological features of Alzheimers disease, including Abeta deposition, excessive Tau phosphorylation and neuroinflammation. AF710B is applicable to the research of Alzheimers disease[1].
Molecular Weight:
357.51
Formula:
C20H27N3OS
Target:
Amyloid-beta,ERK,mAChR,Sigma Receptor,Tau Protein
Application Notes:
MCE Product type: Reference compound
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