A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 µM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer[1].
Molecular Weight:
359.87
CAS Number:
[369358-07-6]
Formula:
C15H22ClN3O3S
Target:
MetAP
Application Notes:
MCE Product type: Reference compound
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