DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562[1].
Molecular Weight:
579.58
Purity:
99.78
CAS Number:
[494786-13-9]
Formula:
C30H31F6N3O2
Target:
Apoptosis,Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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