D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research[1].
Molecular Weight:
454.37
Formula:
C21H26Cl2FN5O
Target:
Dihydrofolate reductase (DHFR) ,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound1
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