NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme[1].
Molecular Weight:
283.11
CAS Number:
[105462-23-5]
Formula:
C7H11NO7P2
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound1
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