ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 µM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines[1][2][3].
Molecular Weight:
263.12
Purity:
99.01
CAS Number:
[931417-26-4]
Formula:
C13H8Cl2N2
Target:
Aryl Hydrocarbon Receptor,Checkpoint Kinase (Chk)
Application Notes:
MCE Product type: Reference compound
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