GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbalpha/REV-ERBalpha (mouse/human reverse erythroblastosis virus alpha) antagonist with EC50s of 21.5 µM and 20.8 µM, respectively. GSK2945 enhances cholesterol 7alpha-hydroxylase (CYP7A1) level and cholesterol metabolism[1].
Molecular Weight:
421.34
CAS Number:
[1438071-12-5]
Formula:
C20H18Cl2N2O2S
Target:
Cytochrome P450,REV-ERB
Application Notes:
MCE Product type: Reference compound
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