L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 µM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes[1][2][3][4].
Molecular Weight:
464.34
CAS Number:
[170228-29-2]
Formula:
C25H19Cl2N3O2
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
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