SB 235375 is a potent and selective antagonist of the human neurokinin-3 (hNK-3) receptor designed by optimizing the structure of 2-phenyl-4-quinolinecarboxylic acid amide. SB 235375 displays high affinity for the hNK-3 receptor, with significantly higher binding affinities than hNK-2 and hNK-1 receptors. In vitro studies demonstrated its ability to block NK-3 receptor-mediated contraction and calcium mobilization, while in vivo, SB 223412 demonstrated oral and intravenous activity against NK-3 receptor-driven responses in animal models[1].
Molecular Weight:
440.49
Purity:
98.13
CAS Number:
[224961-34-6]
Formula:
C27H24N2O4
Target:
Neurokinin Receptor
Application Notes:
MCE Product type: Reference compound
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